Interactions between transforming growth factor beta and signal transducer and activator of transcription 3 in the development of liver fibrosis
10.3760/cma.j.issn.1007-3418.2018.10.014
- VernacularTitle: 转化生长因子β和信号转导和转录激活因子3在肝纤维化发生中的相互作用
- Author:
Wenqing ZHANG
1
;
Guangxiang GU
;
Qiang XIA
Author Information
1. Department of Liver Surgery, the Affiliated Renji Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
- Publication Type:Review
- Keywords:
Liver cirrhosis;
Transforming growth factor β
;
Signal transducer and activator of transcription 3;
Hepatic stellate cells;
Epithelial mesenchymal transition
- From:
Chinese Journal of Hepatology
2018;26(10):792-796
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a common pathological response in chronic liver injury. In the pathological process of hepatic injury, signaling pathways associated with hepatic fibrosis, which mediates the repair, proliferation and fibrosis of the liver secrete different cytokines. In these pathways, transforming growth factor beta (TGFβ) and signal transducer and activator of transcription 3 (STAT3) play key roles in the proliferation and activation of hepatic stellate cells (HSCs) and promote epithelial mesenchymal transition. In addition, it is also involved in the process of proliferation and transformation of collagen and extracellular matrix molecules into myofibroblasts. TGFβ and STAT3 molecular-related signaling pathways mediate the loss of epithelial phenotype and gene expression in mature epithelial cells, transforming them into mesenchymal cells, and producing anti-apoptosis to hepatocytes and promoting the proliferation of HSCs. However, the mechanisms by which STAT3 and TGFβ molecules are involved in the development and progression of liver fibrosis are not sound distinct. In this review, we attempt to know the mechanisms and interactions of TGFβ and STAT3 molecules that mediate potential liver fibrosis, and promote their role in promoting HSCs production and epithelial mesenchymal transition.
