Clinical characteristics and survival analysis of de novo grade 3 or transformed follicular lymphoma patients
10.3760/cma.j.issn.0253-2727.2018.09.009
- VernacularTitle: 52例初治高级别及转化滤泡淋巴瘤患者临床特征及预后分析
- Author:
Zhitao YING
1
;
Haiying FENG
;
Lan MI
;
Yuqin SONG
;
Xiaopei WANG
;
Wen ZHENG
;
Ningjing LIN
;
Meifeng TU
;
Yan XIE
;
Lingyan PING
;
Chen ZHANG
;
Weiping LIU
;
Lijuan DENG
;
Jun ZHU
Author Information
1. Department of Lymphoma, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
- Publication Type:Journal Article
- Keywords:
Lymphoma, follicular;
High grade;
Cell transformation, neoplastic;
Prognosis
- From:
Chinese Journal of Hematology
2018;39(9):745-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical characteristics and survival outcomes of patients with de novo grade 3 or transformed follicular lymphoma (FL).
Methods:Fifty-two patients treated at Peking University Cancer Hospital between January 2009 and September 2017 were assessed, including 28 patients with FL 3A grade, 13 patients with FL 3B grade, 11 patients with transformed FL. Baseline characteristics, survival and prognostic factors were analyzed.
Results:① Twenty-six male and 26 female patients were enrolled, including 28 patients with FL 3A grade, 13 patients with FL 3B grade, 11 patients with transformed FL. ②The 3-year progression-free survival (PFS) and overall survival (OS) for the entire cohort were 56.0% and 80.6%, respectively. Patients with international prognostic index (IPI) score 0-1 demonstrated significantly better 3-year PFS (80.3% vs 20.1%; t=18.902, P<0.001) and OS (95.7% vs 57.0%; t=10.406, P<0.001) than patients with IPI score 2-3. Three-year PFS (94.1% vs 37.2% vs 25.2%; P=0.002) and OS (100.0% vs 76.0% vs 59.8%; P=0.020) were also significantly different among patients with FLIPI 1 score 0-1, 2, ≥3. FLIPI 2 score was also identified as a prognostic factor for 3-year PFS (68.4%, 0, 0; P=0.001) and OS(87.5%, 76.2%, 0; P=0.003). ③Multivariate analysis indicated a significant association of PFS (HR=3.536, P=0.015) and OS (HR=15.713, P=0.015) with IPI. FLIPI 2 was associated with OS (score 0-1, HR=0.078, P=0.007; score 2, HR=0.080, P=0.022).
Conclusion:De novo grade 3 or transformed FL might be a group of curable disease with current treatment strategies. IPI is still a prognostic tool in this scenario.
