Relationship between c-kit mRNA expression and prognosis in patients with rectal carcinoma
10.3760/cma.j.issn.0253-3766.2018.09.005
- VernacularTitle: c－kit mRNA的表达与直肠癌术后患者预后的关系
- Author:
Yanzong LIN
1
;
Yunxia HUANG
2
;
Mingang YING
1
;
Xiangquan KONG
2
;
Fengcun LIN
3
Author Information
1. Department of Gastrointestinal Surgical Oncology, Fujian Medical University Cancer Hospital, Fuzhou 350014, China
2. Department of Abdominal Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou 350014, China
3. Department of Radiation Oncology, Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou 363000, China
- Publication Type:Clinical Trail
- Keywords:
Rectal neoplasms;
C-kit mRNA;
Gene expression;
Prognosis
- From:
Chinese Journal of Oncology
2018;40(9):667-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between c-kit mRNA expression and prognosis in patients with rectal carcinoma.
Methods:The expression of c-kit mRNA in rectal carcinoma tissues(n=66) was detected by multiplex branched-DNA liquid chip method. According to the expression level, the patients were classified into the c-kit mRNA high expression group and the low group. We analyzed the relationship between the c-kit mRNA expression and the clinicopathological characteristics of patients, as well as the factors affecting patients′prognosis.
Results:Of the 66 rectal carcinoma patients, 18(27.3%)cases were c-kit mRNA high expression. No significant correlation was found between the c-kit mRNA expression and gender, age, preoperative carcinoembryonic antigen, preoperative hemoglobin, distance to verge, lymph node metastasis, tumor thrombus, T stage, TNM stage and tumor differentiation (P>0.05). In follow-up, 34 patients died, 32 patients and 36 patients were recurrence or metastasis. The 1-, 3-, 5-year overall survival(OS) of c-kit mRNA high expression group were 100.0%, 77.8%, 77.8%, respectively, while those of the low one were 93.8%, 56.3%, 45.8%, respectively. The difference was statistically significant(P=0.025). Lymph node metastasis, T stage and TNM stage were also significant associated with OS(P<0.05). The 1-, 3-, 5-year disease free rate (DFS)of the c-kit mRNA high expression group were 100.0%, 77.8% and 77.8%, respectively, while those of the low one were 77.1%、43.8% and 41.7%, respectively, and the difference between the two groups was significant (P=0.044). As a reslut, c-kit mRNA expression (P=0.038) and TNM stage (P=0.039) were the independent prognostic factors affecting the OS in rectal cancer patients.
Conclusions:Low expression of c-kit was associated with poor prognosis of rectal carcinoma. And the mechanism underlying this phenomenon deserves further exploration.
