Advances in the research of influence of diabetes in biological function of adipose-derived stem cells

VernacularTitle: 糖尿病对脂肪源性间充质干细胞生物学功能影响的研究进展
Author: Yuanzhen YAO ¹ ; Chengliang DENG ; Bo WANG
Author Information

1. Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China
Publication Type:Review
Keywords: Diabetes mellitus; Wound healing; Adipose-derived stem cells
From: Chinese Journal of Burns 2018;34(9):653-656
CountryChina
Language:Chinese
Abstract: Adipose-derived stem cells (ADSCs) are adult mesenchymal stem cells in adipose tissue with self-renewal and multi-directional differentiation potential. The application of ADSCs in the treatment of wounds has achieved good results. Because of its extensive sources, high content in vivo, low immunogenicity, slight injury to body when obtained, the clinical application prospect of ADSCs is promising. The reasons why diabetic wound is difficult to heal may be closely related to the increase of advanced glycation end products, long-term chronic inflammatory response, and peripheral neurologic dysfunction. The abnormal internal environment of diabetic patients can affect the biological function of ADSCs, which further affects wound healing. This article reviews the general feature, differentiation, proliferation, migration, secretion, and pro-angiogenic function of diabetic ADSCs.