Chronic liver disease increases with damage to intestinal barrier function
10.3760/cma.j.issn.1007-3418.2018.08.010
- VernacularTitle: 慢性肝病增加肠道屏障功能损伤
- Author:
Fenfen LIANG
1
;
Jie WANG
;
Lan LI
;
Yu YUAN
;
Wenrui XIE
;
Lihao WU
;
Xingxiang HE
Author Information
1. Department of Gastroenterology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
Intestinal barrier function;
Fatty liver;
Chronic hepatitis;
Cirrhosis
- From:
Chinese Journal of Hepatology
2018;26(8):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To probe into the correlation between chronic liver disease and intestinal barrier function.
Methods:1 491 cases of hospitalized patients were enrolled, of which 741 cases were of chronic liver diseases, including 397 cases of fatty liver diseases, 230 cases of chronic hepatitis, 114 cases of liver cirrhosis, and 750 cases of non-hepatic diseases. All admitted patients’ intestinal barrier function like diamine oxidase (DAO), D-lactate, lipopolysaccharide, and biochemical indicators of liver functions were tested. According to different data, statistical analysis was done using t-test, ANOVA, Dunnett’s test, χ 2 test of fourfold table, Pearson’s correlation, and binary logistic regression.
Results:The intestinal barrier dysfunction was more likely to occur in the chronic liver disease group than that of non-hepatic disease group [54.15% (379/741) vs. 18.53% (139/750), χ 2 = 193.58, P < 0.001]. The correlation analysis between biochemical indicators of liver function and intestinal barrier function in chronic liver disease group showed that alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), and total bilirubin levels were more susceptible to intestinal barrier dysfunction than those with normal indexes (P < 0.05 ). GGT had stimulated DAO (P < 0.05, OR > 1), D-lactate (P < 0.05, OR > 1), lipopolysaccharide (P < 0.05, OR > 1), ALT and AST.
Conclusion:Chronic liver disease increases with damage to intestinal barrier function.
