Observational study on patients with laryngeal cancer and/or vocal leukoplakia concurrent with laryngopharyngeal reflux
10.3760/cma.j.issn.1673-0860.2018.08.006
- VernacularTitle: 喉癌和声带白斑患者并发咽喉反流的观察研究
- Author:
Jiasen WANG
1
;
Mukun WU
1
;
Jinrang LI
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Navy General Hospital, Beijing 100048, China
- Publication Type:Journal Article
- Keywords:
Laryngopharyngeal reflux;
Laryngeal neoplasms;
Carcinoma, squamous cell;
Vocal cords;
Leukoplakia
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2018;53(8):587-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the incidence and to determine the significance of laryngopharyngeal reflux (LPR) in laryngeal cancer and vocal leukoplakia.
Methods:The patients who had been diagnosed as laryngeal cancer or vocal leukoplakia between January 2014 and June 2017 were included in this study. All of them received 24-hour multichannel intraluminal impedance-pH monitoring. The prevalence of LPR and numerous parameters from the 24-hour pH monitoring in laryngeal cancer patient and vocal leukoplakia patient groups were analyzed. The chi-square test was used for counting data, t test and Mann-Whitney U were used for measuring data.
Results:In the 91 laryngeal cancer patients, the prevalence of pathologic LPR was 28.6%(26/91), the median number[P25, P75, P95]of acid reflux events was 0[0, 3, 5], time of acid exposure was 0[0, 14, 234]s, number of weakly acidic reflux events was 3[0, 6, 11]. In the 54 vocal leukoplakia patients, the prevalence of pathologic LPR was 29.6%(16/54), the number of acid reflux events was 0[0, 3, 4], time of acid exposure was 0[0, 13, 118]s, number of weakly acidic reflux events was 1.5[0, 5, 9]. The incidence of LPR did not vary in the laryngeal cancer patient and vocal leukoplakia patient groups, but were both higher than healthy Chinese volunteers according to a report in the other literature. Furthermore, all the three patients with no history of tobacco or alcohol existed acid or weakly acidic reflux episodes.
Conclusions:Laryngopharyngeal reflux might play a role as an etiologic factor in laryngeal cancer and vocal leukoplakia.
