Primary prevention model of liver cancer in rural China
10.3760/cma.j.issn.0253-3766.2018.07.001
- VernacularTitle: 我国农村地区肝癌一级预防模式的建立
- Author:
Chunfeng QU
1
;
Taoyang CHEN
2
;
Yuting WANG
1
;
Hongyu YAO
2
;
Kun CHEN
1
;
Jian ZHU
2
;
Wanqing CHEN
3
;
Huan HE
1
Author Information
1. State Key Laboratory of Molecular Oncology/Department of Immunology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Qidong People′s Hospital & Qidong Liver Cancer Institute, Qidong 226200, China
3. Office for Cancer Sceening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Review
- Keywords:
Liver neoplasms;
Primary Prevention;
Population-based Study
- From:
Chinese Journal of Oncology
2018;40(7):481-489
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is the major histological type of primary liver cancer (PLC), and the etiology is relative clear. Chronic infection of hepatitis B virus (HBV) plays dominant roles, and high exposure to aflatoxins is an important co-factor. Qidong was one of the endemic area with high PLC incidence in rural China. The results from a series of etiological intervention studies on PLC in this area indicated that 1) the protective efficacy of neonatal HBV vaccination against PLC development under the age of 30 was 84% (95% CI 23%-97%); 2) the relative risk of liver cancer incidence decreased at least 4 folds in young adults aged <35 years with reducing aflatoxin exposures and cleaning drinking water. The prevention of HBV infection and the supplies of clean water and safe food with limited aflatoxins demonstrated as an effective primary prevention model of liver cancer in rural China.
