Value of gadoxetate disodium-enhanced magnetic resonance on hepatobiliary phase T1 mapping for predicting liver injury
10.3760/cma.j.issn.1007-3418.2018.07.010
- VernacularTitle: 钆塞酸二钠增强磁共振肝胆特异期T1 Mappin预测肝脏损伤的价值
- Author:
Chen WANG
1
,
2
,
3
;
Zhicong WANG
;
Ying DING
;
Mengsu ZENG
;
Shengxiang RAO
Author Information
1. Department of Radiology, Zhongshan Hospital, Fudan University
2. Shanghai Institute of Medical Imaging
3. Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hepatitis;
Gadolinium ethoxybenzyl diethy-lenetriamine pentaacetic acid;
T1Mapping;
Liver damage
- From:
Chinese Journal of Hepatology
2018;26(7):530-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the measured value of gadoxetic disodium - enhanced T1-weighted magnetic resonance for the prediction of liver damage (LD) including liver fibrosis and inflammation.
Methods:Retrospectively analyzed laboratory data of 115 patients with pathological results including prothrombin time (PT), albumin, serum total bilirubin level (TBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and magnetic resonance measurements (T1 measurement before and after enhancement and hepatobiliary specific phase T1pre, T1post, and changes in T1 relaxation time before and after enhancement were measured). The correlation between LD and magnetic resonance measurements was assessed by Spearman’s correlation. All cases were divided into two groups: LD < 1 and LD≥1 (n1 = 26, n2 = 89), and the mean value of both groups was compared by t-test or Mann-Whitney U test. The independent influence factors of LD were obtained by binary logistic regression model. The area under receiver operating characteristics (AUROC) curve was performed on T1pre, T1post, and variation values.
Results:Spearman's correlation test showed that T1post and variation values were significantly associated with LD, and the correlation coefficients were 0.435, -0.353 and P < 0.05, respectively. The mean values of T1post, variation values, PT, albumin, ALT and AST were statistically significant (P < 0.05). Binary logistic regression model showed T1post (P = 0.006), PT (P = 0.003), and AST (P = 0.032) were independent influencing factors of LD. T1- post contrast was good predictor of liver damage (AUC = 0.800).
Conclusion:T1-post contrast predicts the existence of liver damage and provides useful information for clinical diagnosis and treatment.
