Opportunistic diseases among HIV-infected patients: a multicenter-nationwide Korean HIV/AIDS cohort study, 2006 to 2013.
- Author:
Youn Jeong KIM
1
;
Jun Hee WOO
;
Min Ja KIM
;
Dae Won PARK
;
Joon Young SONG
;
Shin Woo KIM
;
Jun Yong CHOI
;
June Myung KIM
;
Sang Hoon HAN
;
Jin Soo LEE
;
Bo Youl CHOI
;
Joo Shil LEE
;
Sung Soon KIM
;
Mee Kyung KEE
;
Moon Won KANG
;
Sang Il KIM
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: AIDS-related opportunistic infections; HIV; Korea; Tuberculosis
- MeSH: AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Candidiasis; Cell Count; Cohort Studies*; Cytomegalovirus Infections; Diagnosis; Herpes Zoster; HIV; HIV Infections; Humans; Korea; Mycobacterium tuberculosis; Opportunistic Infections; Pneumocystis jirovecii; Pneumonia; Prevalence; Risk Factors; Sarcoma; Smoke; Smoking; Toxoplasmosis; Tuberculosis
- From:The Korean Journal of Internal Medicine 2016;31(5):953-960
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The frequencies of opportunistic diseases (ODs) vary across countries based on genetic, environmental, and social differences. The Korean HIV/AIDS cohort study was initiated in 2006 to promote research on human immunodeficiency virus (HIV) infection in Korea, and to provide a logistical network to support multicenter projects on epidemiological, clinical, and laboratory aspects of HIV infection. This study evaluated the prevalence of ODs among HIV-infected patients in the era of highly active antiretroviral therapy, and the risk factors associated with ODs. METHODS: The study enrolled 1,086 HIV-infected patients from 19 hospitals. This study examined the baseline data of the HIV/AIDS Korean cohort study at the time of enrollment from December 2006 to July 2013. RESULTS: Candidiasis was the most prevalent opportunistic infection (n = 176, 16.2%), followed by Mycobacterium tuberculosis infection (n = 120, 10.9%), Pneumocystis jirovecii pneumonia (n = 121, 11.0%), cytomegalovirus infection (n = 52, 4.7%), and herpes zoster (n = 44, 4.0%). The prevalence rates of Kaposi’s sarcoma (n = 8, 0.7%) and toxoplasmosis (n = 4, 0.4%) were very low compared with other countries. The risk factors for ODs were a low CD4 T cell count at the time of HIV diagnosis (odds ratio [OR], 1.01; p < 0.01), current smoking (OR, 2.27; p = 0.01), current alcohol use (OR, 2.57; p = 0.04), and a history of tuberculosis (OR, 5.23; p < 0.01). CONCLUSIONS: Using recent Korean nationwide data, this study demonstrated that an important predictor of ODs was a low CD4 T cell count at the time of HIV diagnosis. Tuberculosis remains one of the most important ODs in HIV-infected patients in Korea.
