The preliminary study of white matter integrity in patients with olfactory dysfunction
10.3760/cma.j.issn.1673-0860.2018.07.003
- VernacularTitle: 嗅觉障碍患者脑白质完整性的初步研究
- Author:
Linyin YAO
1
;
Yichen GUO
1
;
Xiaojun ZHAN
1
;
Jia LIU
1
;
Zhifu SUN
1
;
Xing GAO
1
;
Ying LI
2
;
Yongxiang WEI
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
2. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
Olfaction disorders;
White matter;
Diffusion tensor imaging
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2018;53(7):495-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the white matter integrity in patients with olfactory dysfunction using diffusion tensor imaging (DTI).
Methods:Twenty-one patients with olfactory dysfunction and sixteen age, sex and level of education matched normal subjects were recruited in this study. Sniffin′ Sticks olfactory test was performed to evaluate the olfactory function of all subjects. We acquired diffusion tensor images with a echo planar imaging (EPI) sequence from all subjects on a 3T scanner. The fractional anisotropy (FA) images were performed using DTI-studio, and bilateral piriform cortex, orbitofrontal cortex, hippocampus and insula cortex adjacent white matter as well as capsula interna were delineated from the FA images as the region of interest associated with olfactory (ROIawo) manually. Independent sample t test analysis was used to compare the FA value of all ROIawo between the controls and patients.
Results:In olfactory dysfunction group, the FA value of adjacent white matter of right piriform cortex and orbitofrontal cortex were significantly lower than those of control group (0.42±0.05 (±s) vs 0.45±0.05, 0.43±0.06 vs 0.49±0.07, t value was 2.32, 2.79, respectively, all P<0.05). The FA value of adjacent white matter of left piriform cortex and orbitofrontal cortex had no significant difference compared with those of control group (0.43±0.05 vs 0.45±0.04, 0.44±0.04 vs 0.47±0.06, t value was 1.65, 1.37, respectively, all P>0.05). The FA value of the adjacent white matter of bilateral hippocampus, insula cortex and capsula interna had no significant difference compared with those of control group, neither (0.45±0.08 vs 0.44±0.08, 0.45±0.09 vs 0.44±0.10, 0.41±0.08 vs 0.39±0.07, 0.41±0.07 vs 0.38±0.05, 0.64±0.08 vs 0.63±0.08, 0.64±0.07 vs 0.63±0.07, t value was 0.30, 0.15, 0.88, 1.34, 0.14, 0.35, respectively, all P>0.05).
Conclusions:The patients with olfactory dysfunction showed abnormal white matter connection in the major primary and secondary olfactory cortex. The reduced white matter integrity in ROIawo might contribute to the pathogenesis of olfactory dysfunction.
