Gastrointestinal leiomyoma with interstitial cells of Cajal: mimicker of gastrointestinal stromal tumor
10.3760/cma.j.issn.0529-5807.2018.06.010
- VernacularTitle: 消化道平滑肌瘤中存在Cajal间质细胞：警惕误诊为胃肠道间质瘤
- Author:
Guiming HU
1
;
Yikun FENG
;
Qiuyu LIU
;
Huiping CHEN
;
Wenjing FU
;
Min ZHANG
;
Jia CHANG
;
Bin GU
;
Huifang WU
;
Jingli REN
Author Information
1. Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China
- Publication Type:Journal Article
- Keywords:
Gastrointestinal neoplasms;
Leiomyoma;
Gastrointestinal stromal tumors;
Interstitial cells of Cajal
- From:
Chinese Journal of Pathology
2018;47(6):438-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study clinical and pathologic characteristics of leiomyomas of the gastrointestinal tract, and to investigate the distribution characteristics of interstitial cells of Cajal ( ICCs ) in gastrointestinal leiomyomas.
Methods:One hundred and forty-seven cases of leiomyomas of gastrointestinal tract were collected at the Second Affiliated Hospital of Zhengzhou University from June 2012 to June 2017. Clinical and pathologic findings were analyzed, combined with immunohistochemistry, Alcian blue-osafranin staining and molecular study.
Results:The age of patients ranged from 13-82 years with mean age of 52 years. Male to female ratio was about 1∶2. Histologically, all tumors were composed of ovoid to spindle cells arranged in short intersecting fascicles. All tumors were diffusely and strongly positive for smooth muscle antibodies, desmin and h-caldesmon by immunohistochemical staining. A prominent interspersed subpopulation of elongated/dendritic-like cells with CD117 and DOG1 positivity (accounting for 1% to 30% of all tumor cells) and negative for Alcian blue-osafranin staining was identified in all esophageal leiomyomas, 16 of 20 (80%) gastric leiomyomas and 3 of 12 small bowel leiomyomas, but none in colonic/rectal leiomyomas. Mutational analysis in 16 cases showed absence of mutation in exons 9, 11, 13 or 17 of C-KIT and exons 12 or 18 of PDGFRA.
Conclusions:ICCs are identified in esophageal and gastric leiomyomas, as well as in small percentage of intestinal leiomyomas. Such findings may bring significant diagnostic pitfalls for misdiagnosis as gastrointestinal stromal tumor. Careful attention to the distribution of CD117 and DOG1 positive cells and molecular mutation analysis of C-KIT and PDGFRA may be necessary to establish the correct diagnosis.
