Prognostic significance of CLL-IPI for Chinese patients with chronic lymphocytic leukemia
10.3760/cma.j.issn.0253-2727.2018.05.009
- VernacularTitle: CLL-IPI评分系统在中国慢性淋巴细胞白血病患者中的预后评估价值
- Author:
Huayuan ZHU
1
;
Li WANG
;
Jia QIAO
;
Yixin ZOU
;
Yi XIA
;
Wei WU
;
Lei CAO
;
Jinhua LIANG
;
Lei FAN
;
Wei XU
;
Jianyong LI
Author Information
1. Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, China
- Publication Type:Journal Article
- Keywords:
Leukemia, lymphocytic, chronic, B-cell;
Prognosis
- From:
Chinese Journal of Hematology
2018;39(5):392-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To validate the prognostic value of chronic lymphocytic leukemia-international prognostic index (CLL-IPI) for Chinese CLL patients.
Methods:Two hundred and fifteen CLL patients who were initially diagnosed and treated in Jiangsu Province Hospital from January 2002 to November 2017 were included in the retrospective analysis. Risk stratification and prognosis were evaluated by CLL-IPI scoring system.
Results:①Of the 215 patients, 143 were males and 72 were females, with a median age of 60 (16-85) years old. The median treatment-free survival (TFS) and overall survival (OS) was 16 months (4-24 months) and 180 months (145-215 months), respectively. ② The median TFS for low (n=60), intermediate (n=50), high (n=45) and very high risk group (n=60) according to the CLL-IPI scoring system was 56, 15, 12 and 5 months, respectively (P<0.001). ③ The median follow-up was 48 months (1-192 months). The median OS for low risk group was not reached and for intermediate, high, and very high risk group was 180, 89 and 74 months, respectively. The estimated 5-year OS rate was 97.6%, 83.7%, 67.8% and 55.2%, respectively (P<0.001). ④ Multivariate analysis indicated that unmutated immunoglobulin heavy chain variable region (IGHV) gene and β2-microglobulin>3.5 mg/L(P<0.001) were independent prognostic factors of TFS, while TP53 deletion and/or mutation(P=0.008), unmutated IGHV (P=0.017) and age>65 years(P=0.045) were independent prognostic factors of OS.
Conclusion:CLL-IPI is the powerful tool for risk stratification in Chinese CLL patients.
