A retrospective study on combined modality therapy with or without surgery for advanced hypopharyngeal squamous cell carcinoma: an analysis of 119 cases

Yongxia Zhang; Honghua Peng; Xinxin Zhang; Jiandong Zhao; Wenming WU; Jialing Wang; Deliang Huang; Liang Zong; Liwei Chen; Chenqing Liu; Mingbo Liu

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A retrospective study on combined modality therapy with or without surgery for advanced hypopharyngeal squamous cell carcinoma: an analysis of 119 cases

VernacularTitle: 晚期下咽癌119例手术与非手术综合治疗临床分析
Author: Yongxia ZHANG ¹ ; Honghua PENG ² ; Xinxin ZHANG ¹ ; Jiandong ZHAO ¹ ; Wenming WU ¹ ; Jialing WANG ¹ ; Deliang HUANG ¹ ; Liang ZONG ¹ ; Liwei CHEN ¹ ; Chenqing LIU ¹ ; Mingbo LIU ¹
Author Information

1. Department of Otorhinolaryngology Head and Neck Surgery, Chinese People Liberation Army General Hospital, Beijing 100853, China
2. Department of Otorhinolaryngology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China
Publication Type:Journal Article
Keywords: Hypopharyngeal neoplasm; Carcinoma, squamous cell; Surgery; Chemoradiation; Combined modality therapy
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2018;53(5):352-358
CountryChina
Language:Chinese
Abstract: Objective:To compare the treatment outcomes for locally advanced hypopharyngeal carcinoma between surgery plus radio(chemo) therapy(SRT) and non-surgery chemoradiotherapy(CRT).
Methods:A total of 119 patients diagnosed with advanced hypopharyngeal carcinoma without distant metastases between 2010 and 2014 were identified in the Chinese People′s Liberation Army General Hospital, and they were divided into 2 groups: 42 cases in SRT group and 77 cases in CRT group. Patients′ clinical information was collected. Survival rates and prognostic factors were analyzed by the Kaplan-Meier method with SPSS 23.0 software. The survival rates, laryngeal preservation rates and complication rates were compared between the two groups using the chi-square test.Among the 119 patients, 112 were males and 7 were females. Age ranged from 27 to 78 years, with an average age of 57 years.
Results:There were no significant difference between the SRT and CRT group for five-year disease-free survival (DFS, 53.9% vs. 45.1%, χ²=1.251, P=0.263) and overall survival (OS, 54.9% vs. 45.6%, χ²=1.749, P=0.186). Compared to SRT group, CRT group did not showed the significant increase of treatment complications (χ²=0.858, P=0.354), with a higher laryngeal preservation rate (50.0% vs. 71.4%, χ²=6.493, P=0.011).
Conclusions:Advanced hypopharyngeal carcinoma is of high malignancy and poor prognosis. Combined modality treatment is a main approach for advanced hypopharyngeal cancer. SRT offers disease-free survival and overall survival rates equivalent to CRT, but with a higher laryngeal preservation rate.