Clinical analysis of seven cases of rare hemolytic disease of the newborn
10.3760/cma.j.issn.0578-1310.2018.05.012
- VernacularTitle: 少见新生儿溶血病七例临床分析
- Author:
Song GU
1
;
Huixin WANG
;
Caiyun YANG
;
Xuefang YANG
;
Ying LIN
;
Yan ZHONG
;
Jianping HE
;
Yajuan WANG
Author Information
1. Department of Neonatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
- Publication Type:Clinical Trail
- Keywords:
Erythroblastosis, fetal;
Blood group incompatibility;
MNSS blood-group system;
Kidd blood-group system;
Duffy blood-group system
- From:
Chinese Journal of Pediatrics
2018;56(5):369-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical features of 7 rare cases of hemolytic disease of newborn (HDN), and to improve the understanding of rare HDN.
Methods:Data of clinical information, laboratory findings, treatments and outcomes were collected and analyzed for four cases with HDN due to anti-M, two cases due to anti-Kidd, and one case due to anti-Duffy. All of them were admitted to the Department of Neonatology, Beijing Children's Hospital Affiliated to Capital Medial University from July 2007 to June 2017.
Results:Among the four MN hemolytic babies, two were males and two were females. Jaundice was found in three cases. Two cases had hyperbilirubinemia, one of them had severe hyperbilirubinemia. All the four cases developed anemia, including severe anemia in three cases. Two cases of Kidd hemolytic disease and 1 case of Duffy hemolytic disease had jaundice and anemia, but did not reach the level of severe hyperbilirubinemia and severe anemia. MN hemolytic disease babies got negative results in direct antiglobulin test, whereas the Kidd and Duffy hemolytic disease babies had positive findings in direct antiglobulin test. None of the babies had blood transfusion, and they were discharged from the hospital.
Conclusions:Without maternal and fetal blood group incompatibility (ABO or Rh blood-group system), for early onset of jaundice, severe jaundice or anemia, antiglobulin test to mother and child earlier should be administered, and MN, Kidd, Duffy and other rare hemolytic disease of the newborn should be pay attention to.
