Roles of HPV detection in 28 923 patients with atypical squamous cells of undetermined significance: analysis of 104 studies from China
10.3760/cma.j.issn.0529-5807.2018.04.008
- VernacularTitle: 人乳头状瘤病毒检测在28 923例不能明确意义的不典型鳞状细胞患者中的应用：中国104项研究汇总分析
- Author:
Zeni WU
1
;
Zheng SU
;
Wen CHEN
;
Youlin QIAO
Author Information
1. Department of Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Cervix uteri;
Cytological techniques;
Atypical squamous cells of unknown significance
- From:
Chinese Journal of Pathology
2018;47(4):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the human papillomavirus (HPV) positive rate and its usefulness in predicting CIN2+ in women with atypical squamous cells of undetermined significance (ASC-US) cervical cytology.
Methods:A pooled analysis was conducted using published data of hospital classification, HPV positive rate and histopathologic diagnosis in ASC-US population during 2005 to 2017 from 104 studies which enrolled 28 923 ASC-US samples.
Results:The overall HPV positive rate was 52.09% (range from 12.06% to 88.68%). The HPV positive rate in 79 tertiary hospitals of 21 244 cases was 52.46%, slightly higher than the 50.87% in 22 second-class hospitals of 6 925 cases. There was no significant difference between specialized hospitals and general hospitals. In addition, the positive rate of HC2 conducted in 66 hospitals with 19 791 cases was 53.13%, which was slightly higher than 51.10% of reverse hybridization from 24 hospitals with 6 338 cases. In 73 studies of 18 163 cases with histological diagnosis, the sensitivity of HPV for detecting CIN2+ was 90.16% (95%CI: 88.91% to 91.28%), specificity was 53.08% (95%CI: 53.02% to 54.57%), positive predictive value was 23.24% and negative predictive value was 97.24%.
Conclusion:HPV detection is clinically validated for ASC-US triage, but there is a wide variation of HPV positive rate in population of cervical cytological diagnosis as ASC-US in China, suggesting different diagnostic level between regions and hospitals and further improvement is needed.
