Association between the ratio of early diastolic transmitral velocity to early diastolic mitral annular velocity and invasive measured left atrial pressure in patients with atrial fibrillation and preserved left ventricular ejection fraction
10.3760/cma.j.issn.0253-3758.2018.04.008
- VernacularTitle: 二尖瓣舒张早期血流峰速度与二尖瓣环舒张早期运动峰速度比值对于心房颤动患者左心房压力的诊断价值
- Author:
Gaigai MA
1
;
Ligang FANG
;
Peng GAO
;
Zhongwei CHENG
;
Taibo CHEN
;
Xue LIN
;
Kang'an CHENG
;
Hua DENG
;
Quan FANG
Author Information
1. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
- Publication Type:Clinical Trail
- Keywords:
Atrial fibrillation;
Echocardiography,stress;
Diagnosis;
Left atrial pressure
- From:
Chinese Journal of Cardiology
2018;46(4):292-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between the ratio of early diastolic transmitral velocity to early diastolic mitral annular velocity (E/E') and left atrial pressure (LAP) estimated from invasive catheter measurements in patients with atrial fibrillation (AF).
Methods:A total of 46 consecutive patients with non-valvular AF and preserved left ventricular ejection fraction (LVEF) admitted in our department to receive the first radiofrequency ablation from May to July 2017 were included. All patients underwent echocardiography at 24-48 hours before radiofrequency ablation, and LAP was invasively measured during the ablation procedure. According to mean LAP, patients were divided into 2 groups of normal LAP (LAP≤12 mmHg(1 mmHg=0.133 kPa, n=31) and elevated LAP (LAP>12 mmHg, n=15). Linear correlation analysis was used to evaluate the relationship between E/E' and LAP.
Results:E/E' correlated well with LAP (septal E/E' (E/E'sep), r= 0.397, P=0.006; lateral E/E' (E/E'lat), r=0.433, P=0.003; mean E/E' (E/E'mean), r=0.431, P=0.003). Using receiver operating characteristic analysis, the optimal cut-off for E/E'sep was 12.5 (sensitivity 73.3%, specificity 67.7%), E/E'lat was 10.8 (sensitivity 80.0%, specificity 77.4%), E/E'mean was 11.0 (sensitivity 86.7%, specificity 64.5%) to predict mean LAP>12 mmHg.
Conclusion:E/E', especially the E/E'lat, is positively correlated with LAP in patients with AF and preserved LVEF, and may be used to estimate the diastolic function in AF patients with preserved LVEF.
