Prognostic value of myeloperoxidase concentration in patients with acute coronary syndrome
10.3760/cma.j.issn.0253-3758.2018.04.007
- VernacularTitle: 基线血浆髓过氧化物酶水平对急性冠状动脉综合征患者预后的影响
- Author:
Shengcong LIU
1
;
Tieci YI
;
Haoyu WENG
;
Long ZHANG
;
Yuxi LI
;
Momin MOHETABOER
;
Yan ZHANG
;
Jie JIANG
;
Jianping LI
;
Yong HUO
Author Information
1. Department of Cardiology, Peking University First Hospital, Beijing 100034, China
- Publication Type:Clinical Trail
- Keywords:
Acute coronary syndrome;
Myeloperoxidase;
Prognosis
- From:
Chinese Journal of Cardiology
2018;46(4):284-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the difference of plasma myeloperoxidase (MPO) level in different types of acute coronary syndrome (ACS) patients, and the value of baseline MPO level in predicting short-term and long-term outcomes in patients with ACS.
Methods:The study cohort was derived from "the 12th Five-Year" National Science and Technology Support Program Project "Study on Comprehensive Intervention and Prognosis of Acute Coronary Syndrome" . We enrolled all hospitalized ACS patients who were enrolled in "the 12th Five-Year" cohort from January 1, 2011 to December 31, 2013. A total of 630 patients from 20 centers were enrolled. According to the diagnosis, the patients were divided into two groups: ST-segment elevation myocardial infarction (STEMI) group and non-ST-elevation acute coronary syndrome (NSTE-ACS) group. Plasma levels of MPO were measured by ELISA method. Cardiovascular events in the hospital were recorded. All patients were followed-up by telephone, follow-up ended December 31, 2015. The occurrence of major adverse cardiovascular events (MACE, defined as cardiac death, recurrent myocardial infarction, unscheduled coronary revascularization procedure and stroke) and all-cause death were recorded. Logistic regression analysis and Cox regression analysis were used to evaluate the predictive value of baseline MPO levels obtained during hospitalization and the long-term outcomes of ACS patients.
Results:A total of 597 ACS patients were enrolled in final analysis. Level of plasma MPO in STEMI patients was significantly higher than that of NSTE-ACS patients (34.02(19.31, 67.87) μg/L vs. 27.25(16.69, 52.92) μg/L, P=0.028) . MPO was not related to the in-hospital cardiovascular events (OR=0.797, 95%CI 0.366-1.737, P=0.569). Follow up was completed in 476 patients, median follow-up time was 796 (32, 1 816) days. There were 23 all-cause deaths and 51 MACE. Plasma MPO level was not an independent predictor for all-cause death (HR=1.434, 95%CI 0.502-4.100, P=0.501) and MACE (HR=1.271, 95%CI 0.662-2.442, P=0.471).
Conclusion:In hospitalized ACS patients, level of plasma MPO was significantly higher in STEMI patients than in NSTE-ACS patients, but MPO could not predict the short-term or long-term outcomes in patients with ACS.
