Expression of βF1 and T cell receptor γ in T lymphoblastic lymphoma/leukemia
10.3760/cma.j.issn.0529-5807.2018.02.008
- VernacularTitle: T细胞抗原受体(TCR)标志物βF1及TCRγ在T淋巴母细胞淋巴瘤/白血病中的表达
- Author:
Fen ZHANG
1
;
Donglan LUO
;
Yu CHEN
;
Hongmei WU
;
Jinhai YAN
;
Xinlan LUO
;
Jiao HE
;
Luqiao LUO
;
Yanhui LIU
Author Information
1. Department of Pathology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
Precursor cell lymphoblastic leukemia-lymphoma;
Genes, T-cell antigen receptor;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2018;47(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the expression of βF1 and T cell receptor (TCR)γ in T lymphoblastic lymphoma/leukemia(T-LBL/ALL), and investigate the clinicopathological features.
Methods:Fifty-one cases of T-LBL/ALL were collected at Guangdong General Hospital from 2010 to 2016, the expression of βF1 and TCRγ was assessed by immunohistochemistry.
Results:There were 13 cases of children and adolescents, and 38 cases of adults. The expression rates of βF1 and TCRγ were 27.5%(14/51) and 15.7%(8/51) respectively. The proportion of adults in αβ T-LBL/ALL, TCR-silent T-LBL/ALL and γδ T-LBL/ALL was 7/14, 79.3%(23/29)and 8/8 respectively, and the difference was significant (P=0.023). There was no statistical difference in sex, LDH, bone marrow involvement and Ann arbor stage among these three groups(P>0.05). γδ T-LBL/ALLs included 6 cases of CD4-/CD8- phenotype, whereas αβ T-LBL/ALL included 7 cases of CD4+ /CD8+ phenotype. There was significant difference in CD4/CD8 expression among these three groups(P<0.01).
Conclusions:γδ T-LBL/ALL occurred only in adults, with predominantly CD4-/CD8- phenotype. αβ T-LBL/ALL occurred more common in children and adolescents, with predominantly CD4+ /CD8+ phenotype.
