Clinicopathologic features and prognosis of inflammatory pseudotumor-like follicular dendritic cell sarcomas in liver and spleen: an analysis of seven cases
10.3760/cma.j.issn.0529-5807.2018.02.007
- VernacularTitle: 肝脏/脾脏炎性假瘤样滤泡树突细胞肉瘤七例临床病理特征及预后
- Author:
Youli WU
1
;
Feng WU
;
Lan YANG
;
Hui SUN
;
Xiaochu YAN
;
Guangjie DUAN
Author Information
1. Department of Pathology, the First Affiliated Hospital, Army Medical University (Third Military Medical University), PLA, Chongqing 400038, China
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Splenic neoplasms;
Dendritic cell, follicular;
Diagnosis;
Prognosis
- From:
Chinese Journal of Pathology
2018;47(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features and prognostic parameters of the inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of liver and spleen.
Methods:Ninteen cases of inflammatory pseudotumor (IPT) and 5 cases of IPT-like FDCS of the liver and spleen were collected at the First Affiliated Hospital, Army Medical University from 2006 to 2016. HE sections, immunohistochemical staining, and Epstein-Barr virus encoded nuclear RNA (EBER) in situ hybridization were reviewed along with a summary of the literature.
Results:Among the previously diagnosed 19 cases of IPT of the liver and spleen, 2 cases were misdiagnosed (the ratio of 2/19). Among 7 new cases including 3 males and 4 females, 3 cases involved the liver and 4 cases involved the spleen. The age range was 37-64 years (mean 53 years). The maximum tumor diameter ranged from 3.0 to 11.0 cm (mean 6.5 cm). Surgical resections were performed in all patients with follow-up time ranging from 3 to 84 months.All patients were disease-free.7 new cases were all positive for EBER, and showed the expression of at least one of the FDC markers, including CD21, CD23, and CD35. The rest of 17 cases of IPT were all negative for EBER and essentially negative for FDC markers, but were all positive for SMA.
Conclusions:IPT-like FDCS of the liver and spleen is a rare low-grade malignant tumor morphologically mimicking inflammatory pseudotumor, and is easy to be misdiagnosis due to under-recognition. EBER in situ hybridization and FDC markers are indispensable for confirming the diagnosis.
