Prevalence and clinical features of familial hypercholesterolemia in Chinese patients with myocardial infarction
10.3760/cma.j.issn.0253-3758.2018.02.008
- VernacularTitle: 心肌梗死患者家族性高胆固醇血症检出及临床特点分析
- Author:
Di SUN
1
;
Sha LI
;
Chenggang ZHU
;
Yuanlin GUO
;
Naqiong WU
;
Ying GAO
;
Ping QING
;
Yan ZHANG
;
Geng LIU
;
Qian DONG
;
Jianjun LI
Author Information
1. Division of Dyslipidemia, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Familial hypercholesterolemia;
Prevalence;
Risk factors
- From:
Chinese Journal of Cardiology
2018;46(2):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and clinical features of familial hypercholesterolemia (FH) in Chinese patients with myocardial infarction (MI).
Method:This retrospective study recruited a total of 2 119 consecutive patients (age (56.7±10.9) years old) undergoing coronary angiography with first MI from April 2011 to December 2016. Patients were divided into 2 groups: premature MI (male<55 years old, female<60 years old) and non-premature MI. The diagnosis of FH was established according to Dutch Lipid Clinic Network (DLCN) diagnostic criteria and referred as definite/probable FH in our study. The prevalence and clinical features of FH, including lipid level, MI characteristics and stain therapy, were explored. Multivariable logistic regression analysis was used to assess the predictive value of FH for the presence of premature MI.
Results:The prevalence of definite/probable FH was 3.68% (78/2 119) in MI patients and 7.28% (68/934) in premature MI patients. Onset of MI occurred 10 years earlier in patients with definite/probable FH than those without FH ((47.9±9.4) years vs. (58.8±10.7) years, P<0.01). Additionally, we found that the risk of premature MI was significantly and independently increased in definite/probable FH patients (OR=5.32, 95%CI 2.77-10.22, P<0.01). None of FH patients reached the target of LDL-C<1.8 mmol/L under statin therapy.
Conclusions:The prevalence of FH in Chinese patients with MI is not rare. Clinically, FH is linked with the early onset of MI.
