A Multicenter Clinical Trial of Cisapride Tartrate in Diabetic Patients with Dysmotility Like Dyspeptic Symptoms.
- Author:
Sun Myung KIM
1
;
Kyo Young CHOO
;
Myung Gyu CHOI
;
Jin Il KIM
;
Choon Sang BHANG
;
Sok Won HAN
;
Byung Wook KIM
;
Hwang CHOI
;
Sung Soo KIM
;
Dong Soo LEE
;
Kyu Yong CHOI
;
Moo Il KANG
;
In Sik CHUNG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. choim@cmc.cuk.
- Publication Type:Clinical Trial ; Multicenter Study ; Original Article
- Keywords:
Cisapride tartrate;
Dyspepsia;
Diabetes
- MeSH:
Cisapride*;
Dizziness;
Dyspepsia;
Gastric Emptying;
Glucose;
Hemoglobin A, Glycosylated;
Humans;
Meals;
Nausea
- From:Korean Journal of Gastrointestinal Motility
2001;7(1):56-64
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: We evaluated the effects of cisapride tartrate on gastrointestinal symptoms and gastric emptying times in diabetic patients with dysmotility like dyspeptic symptoms. METHODS: Cisapride was administered before each meal in 61 patients for 4 weeks. The intensity of gastrointestinal symptoms before and after cisapride administration was scored from 0 to 4, in the order of increasing severity of symptoms. In addition, a gastric emptying test was performed. RESULTS: A significant reduction in the total intensity score of symptoms was observed during the first two weeks, from 8.5+/-2.1 to 4.0+/-3.0 (p < 0.05), and a further reduction was noted during the next two weeks, to 2.8+/-2.8 (p < 0.05). Good to excellent improvement was obtained in 70.4% of the patients, but the improvement in symptoms was not related to age, duration of diabetes, glucose, Hb A1c, neuropathy, or retinopathy. Treatment with cisapride induced a significant regression of symptoms and a significant improvement of delayed gastric emptying from 104.0+/-31.7 minutes to 79.5+/-17.1 (p < 0.05). However, there was a lack of association between the changes in gastric emptying times and improvements in symptoms(r(2)=0.00186). Only 3 patients complained of loose stool, nausea, or dizziness. CONCLUSIONS: Cisapride was effective in improving dysmotility like dyspeptic symptoms in diabetic patients without serious side effects.