Factors Associated with HIV-1 Proviral DNA Loads in Patients with Undetectable Plasma RNA Load.
10.3346/jkms.2009.24.1.152
- Author:
Jun Yong CHOI
1
;
Young Goo SONG
;
Young Hwa KIM
;
Chang Oh KIM
;
Myung Soo KIM
;
Bum Sik CHIN
;
Sang Hoon HAN
;
Suk Hoon CHOI
;
Han Sung LEE
;
Su Jin JEONG
;
Heekyoung CHOI
;
June Myung KIM
Author Information
1. Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. jmkim@yuhs.ac
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
HIV;
HIV Infections;
Acquired Immunodeficiency Syndrome;
Proviruses
- MeSH:
Anti-HIV Agents/therapeutic use;
Antiretroviral Therapy, Highly Active;
CD4-Positive T-Lymphocytes/virology;
Cross-Sectional Studies;
DNA, Viral/*analysis;
Female;
HIV Infections/drug therapy;
HIV-1/*genetics;
Humans;
Male;
Polymerase Chain Reaction;
Proviruses/*genetics;
RNA, Viral/blood
- From:Journal of Korean Medical Science
2009;24(1):152-154
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1- infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microliter without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microliter without HAART could help reduce HIV-1 proviral DNA load.
