Research advances in pathogenesis of autoimmune hepatitis
10.3760/cma.j.issn.1007-3418.2017.12.016
- VernacularTitle: 自身免疫性肝炎的发病机制研究进展
- Author:
Pingping ZHAO
1
;
Zhihua DENG
Author Information
1. Department of Gastroenterology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Hepatitis, autoimmune;
Patho-mechanism
- From:
Chinese Journal of Hepatology
2017;25(12):957-960
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune hepatitis (AIH) is liver parenchymal inflammation mediated by the autoimmune response of hepatocytes. Its clinical features include elevation of aminotransferases in serum, presence of various autoantibodies in circulation, hypergammaglobulinemia, and interface hepatitis in liver tissue. Although the etiology and pathogenesis of AIH have not been fully elucidated, a consensus has been reached on the theories of "genetic susceptibility" and "molecular simulation" , and "immunoregulatory disorder" remains a hot research topic for many scholars. This article reviews the research advances in the theories of "genetic susceptibility" , "molecular simulation" , and "immunoregulatory disorder" .
