Role of nuclear factor-κB activation in sepsis-induced myocardial dysfunction
10.3760/cma.j.issn.1009-2587.2017.12.014
- VernacularTitle: 核因子κB活化在脓毒症所致心肌损伤中的作用
- Author:
Hao ZHOU
1
;
Guangqing WANG
;
Pengfei LUO
;
Zhaofan XIA
Author Information
1. Department of Burn Surgery, Institute of Burns, Changhai Hospital, Naval Medical University, Shanghai 200433, China
- Publication Type:Review
- Keywords:
NF-kappa B;
Sepsis;
Cardiomyopathies;
Apoptosis;
Autophagy;
Inflammatory cytokine
- From:
Chinese Journal of Burns
2017;33(12):782-784
- CountryChina
- Language:Chinese
-
Abstract:
As a common complication in patients with sepsis, cardiac dysfunction may significantly increase mortality of these patients, but its mechanism is still unclear. Nuclear factor-κB (NF-κB) is a pleiotropic transcription inducing factor, which involves in the regulation of multiple biological phenomena and disease status. NF-κB activation participates in cardiomyocyte apoptosis, cardiomyocyte autophagy, and release of inflammatory cytokines in patients with sepsis, indicating its important role in sepsis-induced myocardial dysfunction.
