Association between biomarkers and activities of daily living in the elderly ≥65 years old from longevity areas in China
10.3760/cma.j.issn.0253-9624.2017.11.011
- VernacularTitle: 中国长寿地区65岁及以上老年人生物标志物与日常生活自理能力的关系
- Author:
Jiesi LUO
1
;
Yuebin LYU
;
Zhaoxue YIN
;
Wenhui SHI
;
Juan ZHANG
;
Liqin SU
;
Jianlong FANG
;
Xiaoming SHI
Author Information
1. Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Journal Article
- Keywords:
Longevity;
Aged;
Lymphocyte count;
Cohort studies;
Activities of daily living
- From:
Chinese Journal of Preventive Medicine
2017;51(11):1012-1018
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between biomarkers and activities of daily living (ADL) in the elderly over 65 years old from longevity areas in China.
Methods:A total of 2 439 people from 8 longevity areas were included in our baseline survey in 2012. Using questionnaires, body measurements, and blood biochemical examinations, information on demographics characteristic, life style, ADL, blood pressure and biomarkers were collected. Based on these six items of ADL (bathing, dressing, indoor activities, toileting, eating, bowel and bladder control), we constructed a dichotomous indicator for ADL. A respondent was defined as ADL disabled if any difficulty in one or more of the above six activities was reported. Information were collected in the follow-up in 2014 using the same questionnaires and examinations. We excluded information on the elderly who lacked ADL or biomarkers test results or with ADL disability at baseline study. Finally 938 elderly people over 65 years old were included in this analysis. Multivariate logistic regression model was used to analyze the influence factors of ADL disability.
Results:During the 2-year follow-up, 100 (10.7%) participants developed into ADL disability, with a rate at 10.7%. Multivariate logistic regression analysis indicated that each year increase in age or each 1 mmHg (1 mmHg=0.133 kPa) increase in systolic blood pressure (SBP) would cause the risk of ADL disability to increase 9% or 1%, whose OR (95%CI) were separately 1.09 (1.06-1.12), 1.01 (1.00-1.02). Han nationality or cognitive impairment increased the risk of ADL disability, whose OR (95%CI) values were separately 4.90 (1.13-21.24), 2.47 (1.44-4.25), while increased lymphocyte count (>1.60×109/L), being married, or participating in recreational activities decreased the risk of ADL disability, whose OR (95%CI) values were separately 0.51 (0.31-0.82), 0.52 (0.28-0.96), 0.43 (0.23-0.80).
Conclusion:In the elderly elevated lymphocyte count was associated with lower risk of ADL disability. In addition, incresed age, increased SBP, unmarried, Han nationality or cognitive impairment were associated with the increasing risk of ADL disability in older people, while participating in recreational activities would reduce the risk.
