The difference expression and diagnostic value of RPL5 in papillary thyroid carcinoma of children and adults
10.3760/cma.j.issn.1673-0860.2017.11.006
- VernacularTitle: RPL5在儿童和成人甲状腺乳头状癌中的差异表达及其诊断价值
- Author:
Yaqiong JIN
1
;
Shengcai WANG
2
;
Jun TAI
2
;
Jie ZHANG
2
;
Feng CHEN
2
;
Jin SHI
1
;
Yongbo YU
1
;
Yeran YANG
1
;
Huimin REN
1
;
Di GENG
1
;
Yuanhu LIU
2
;
Yongli GUO
1
;
Xin NI
2
Author Information
1. Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China
2. Department of Otolaryngology, Head and Neck Surgery, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China
- Publication Type:Journal Article
- Keywords:
Ribosomal proteins;
Thyroid neoplasms;
Carcinoma, papillary;
Diagnostic value;
Receiver operating characteristic curve
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(11):830-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the difference expression and diagnostic value of ribosomal protein L5 (RPL5) in papillary thyroid carcinoma (PTC) of children and adults.
Methods:Realtime-PCR was performed to detect the expression of RPL5 in 22 PTC tissues and 13 pericarcinous tissues. Receiver operating characteristic (ROC) curve and Youden's index were used to evaluate the diagnostic value of RPL5 in PTC of children and adults.
Results:The expression of RPL5 in PTC tissues was higher than in pericarcinous tissues. The area under curve (AUC) was 0.820 (P=0.001), and Youden′s index was 0.568. The expression of RPL5 in PTC of adults was higher than children (P<0.05). The AUC and Youden's index were respectively 0.721 (P=0.069) and 0.414 in children, whereas being respectively 0.896 (P=0.0005) and 0.709 in adults. RPL5 in diagnosis of PTC of adults was better than CK19, Galectin-3 and TPO, which are commonly used for the pathologic diagnosis of PTC.
Conclusion:The expression of RPL5 in PTC is higher than pericarcinous tissues, and its expression in PTC of adults is higher than children. Furthermore, PTC is a potential indicator for diagnosis of PTC.
