Characteristics of ERG, Fli-1, CD34, CD31 and FⅧRAg expression in hepatic malignant vascular tumors
10.3760/cma.j.issn.0529-5807.2017.11.005
- VernacularTitle: 肝脏恶性血管源性肿瘤中ERG、Fli－1、CD34、CD31、FⅧRAg的表达特征
- Author:
Zhanbo WANG
1
;
Xiaojing AN
;
Jinfang DENG
;
Jinhong LIU
;
Huaiyin SHI
Author Information
1. Department of Pathology, the Chinese PLA General Hospital, Beijing 100853, China
- Publication Type:Journal Article
- Keywords:
Liver;
Vascular neoplasms;
Proto-oncogene protein c-fli-1
- From:
Chinese Journal of Pathology
2017;46(11):760-763
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of ERG, Fli-1, CD34, CD31 and factor Ⅷ-related antigen(FⅧRAg) in hepatic malignant vascular tumors.
Methods:A retrospective analysis was conducted on 63 cases of primary hepatic malignant vascular tumors and 31 cases of hepatic other malignant spindle cell tumors collected during January 1986 to January 2014. EnVision method was used to detect the expression of ERG, Fli-1, CD34, CD31, FⅧRAg.
Results:Sixty-three cases of malignant vascular tumors, including 24 cases of angiosarcoma, 38 cases of epithelioid hemangioendothelioma and 1 case of hepatic Kaposi′s sarcoma. All of the cases were positive for ERG(100.0%, 63/63). Positive rate of Fli-1, CD34, CD31, FⅧRAg was 96.8% (61/63), 87.3% (55/63), 81.0% (51/63) and 41.3% (26/63), respectively. In other hepatic malignant spindle cell tumors, the positive rate of ERG, Fli-1, CD34, CD31 and FⅧRAg was 3.2% (1/31), 19.4% (6/31), 19.4% (6/31), 9.7%(3/31) and 3.2%(1/31), respectively.The sensitivity of ERG, Fli-1, CD34, CD31, FⅧRAg was 100.0%, 96.8%, 87.3%, 81.0% and 41.3%, respectively.The specificity was 96.8%, 80.6%, 80.6%, 90.3% and 96.8%, respectively.
Conclusion:ERG is a more sensitive and specific diagnostic marker for hepatic malignant vascular tumors in comparison to Fli-1, CD34, CD31 and FⅧRAg.
