Advances in the research of molecular mechanism of negative pressure wound therapy in improving wound healing
10.3760/cma.j.issn.1009-2587.2017.11.015
- VernacularTitle: 负压伤口疗法促进创面愈合的分子机制研究进展
- Author:
Yang LIU
1
;
Dahai HU
Author Information
1. Burn Center of PLA, Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Medical University, Xi′an 710032, China
- Publication Type:Review
- Keywords:
Negative-pressure wound therapy;
Wound healing;
Cytokines;
Molecular mechanism
- From:
Chinese Journal of Burns
2017;33(11):718-720
- CountryChina
- Language:Chinese
-
Abstract:
Recently, negative pressure wound therapy (NPWT) is a rising technology to improve wound healing. In clinical application, it benefits fast debridement and wound close, limits infection, and promotes wound healing. It is an effective therapy for all kinds of acute or chronic wound. Currently, researches demonstrate that NPWT promotes angiogenesis, granulation tissue growth, and extracellular matrix remodeling through regulating the signaling of anti-inflammatory cytokines, mechanicalreceptor and chemoreceptor, which is related to several growth factors and inflammatory factors. Here we focus on the recent advances in the mechanism of NPWT in promoting wound healing, looking forward to providing a review of NPWT and related researches.
