Effects of baicalin on the changes in hemorheology of acute respiratory distress syndrome in rats
10.3760/cma.j.issn.1001-9391.2017.11.002
- VernacularTitle: 黄芩甙对油酸致急性呼吸窘迫综合征大鼠血液流变学的影响
- Author:
Zanmei ZHAO
1
;
Yimu ZHENG
;
Yanlin ZHANG
;
Shuqiang LI
Author Information
1. Department of Occupational Disease, Peking University Third Hospital, Beijing 100191, China
- Publication Type:Journal Article
- Keywords:
BAICALIN;
Oleic acid;
Respiratory distress syndrome;
Hemorheology
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(11):807-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of baicalin on the changes in hemorheology and its mechanism during the development of Acute Respiratory Distress Syndrome(ARDS) induced by oleic acid (OA) in rats.
Methods:Rats were randomized into 3 groups: control, ARDS (OA induction, 0.12 mg/kg) and ba-icalin-treated group (300 mg/kg). The blood samples were collected at 30 min, 1, 2, 3, 6, 12 and 6 h after OA injection. The whole blood viscosity, plasma viscosity, Maximum erythrocyte deformability index (DImax) were detected. Meanwhile, blood gas analysis and Routine blood test were also performed.
Results:The level of arte-rial oxygen partial pressure and oxygenation index decreased (P<0.01 vs. control) and oxygenation index (178 mm Hg, 1 mm Hg=0.133 kPa) reached the diagnostic standard of ARDS at 2 h in ARDS group. In baicalin-treated group, the level of arterial oxygen partial pressure and oxygenation index increased versus the ARDS group. The platelet count (PLT) decreased in baicalin-treated and ARDS groups. Compared with the ARDS group, the level of PLT increased significantly in baicalin-treated group at 30min, 1, 2, and 3 h. Hematocrit (HCT) increased in baicalin-treated and ARDS groups. Compared with the ARDS group, the level of HCT de-creased significantly in baicalin-treated group at 2, 3, 6 and 12 h. Meanwhile, all the index of hemorheology improved in baicalin-treated group.
Conclusion:Baicalin may improve hypoxemia of ARDS induced by OA in rats. It may be due to the Improvement of microcirculation of lung.
