Prognostic values of grading system for lymph vessel tumor emboli in patients with invasive breast carcinomas of no special type
10.3760/cma.j.issn.0253-3766.2017.10.007
- VernacularTitle: 乳腺非特殊型浸润性癌淋巴管瘤栓分级与预后的关系
- Author:
Meng YUE
1
;
Fang LI
1
;
Huiyan DENG
1
;
Lingling ZHANG
1
;
Yueping LIU
1
Author Information
1. Department of pathology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Clinical Trail
- Keywords:
Breast neoplasms;
Pathology, clinical;
Prognosis;
Grading system for lymph vessel tumor emboli
- From:
Chinese Journal of Oncology
2017;39(10):754-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the grading system for lymph vessel tumor emboli and its prognostic value in patients with invasive carcinomas of no special type (ICNST) of the breast.
Methods:Clinical data of 466patients with ICNST were collected from January 2006 to December 2008 in the Fourth Hospital of Hebei Medical University. The expression levels of D2-40, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2 (HER-2) were analyzed using immunohistochemical staining. Grades for lymph vessel tumoremboli were classified based on the number of mitotic and apoptotic figures in tumor cells under a high-power field. Correlation analysis was performed using Spearman rank correlation test. Kaplan-meier curves and Log-rank tests were used to analyze the survival rate. Multivariate Cox proportional hazard model was used to analyze the prognostic factors.
Results:Among the 466 patients, grades for lymph vessel tumor emboli were categorized as follows: 280 cases were grade 0 (60.1%); 112 cases were grade 1 (24.0%); 58 cases were grade 2 (12.5%); 16 cases were grade 3 (3.4%). Correlation analyses showed that lymph vessel tumor emboli grading system was positively correlated with lymph node metastasis (r=0.365, P<0.001). Kaplan-Meier univariant analysis showed that histological grading, lymph vessel tumor emboli grading system, lymph node metastasis, the expression levels of ER, PR and HER-2 and molecular typing were associated with prognosis of patients (P<0.05 for all). Multivariate analysis of Cox proportional hazard model showed that lymph vessel tumor emboli grading system and lymph node metastasis were independent prognostic factors in patients with ICNST(P<0.05 for all).
Conclusion:Grading system for lymph vessel tumor emboli canpredict the clinical outcome of patients with ICNST.
