Prognostic value of three different staging schemes based on pN, MLR and LODDS in patients with T3 esophageal cancer
10.3760/cma.j.issn.0253-3766.2017.10.006
- VernacularTitle: pN分期淋巴结转移率分期和阳性淋巴结对数比分期预测T3期食管鳞癌患者预后的价值
- Author:
Liang WANG
1
;
Lei CAI
1
;
Qian CHEN
1
;
Youhua JIANG
1
Author Information
1. Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China
- Publication Type:Clinical Trail
- Keywords:
Esophageal neoplasms;
Prognosis;
Lymphatic metastasis
- From:
Chinese Journal of Oncology
2017;39(10):749-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic value of three different staging schemes based on positive lymph nodes (pN), metastatic lymph nodes ratio (MLR) and log odds of positive lymph nodes (LODDS) in patients with T3 esophageal cancer.
Methods:From 2007 to 2014, clinicopathological characteristics of 905 patients who were pathologically diagnosed as T3 esophageal cancer and underwent radical esophagectomy in Zhejiang Cancer Hospital were retrospectively analyzed. Kaplan-Meier curves and Multivariate Cox proportional hazards models were used to evaluate the independent prognostic factors. The values of three lymph node staging schemes for predicting 5-year survival were analyzed by using receiver operating characteristic (ROC) curves.
Results:The 1-, 3- and 5-year overall survival rates of patients with T3 esophageal cancer were 80.9%, 50.0% and 38.4%, respectively. Multivariate analysis showed that MLR stage, LODDS stage and differentiation were independent prognostic survival factors (P<0.05 for all). ROC curves showed that the area under the curve of pN stage, MLR stage, LODDS stage was 0.607, 0.613 and 0.618, respectively. However, the differences were not statistically significant (P>0.05).
Conclusions:LODDS is an independent prognostic factor for patients with T3 esophageal cancer. The value of LODDS staging system may be superior to pN staging system for evaluating the prognosis of these patients.
