Association between intestinal flora imbalance and nonalcoholic fatty liver disease
10.3760/cma.j.issn.1007-3418.2017.10.017
- VernacularTitle: 肠道菌群失衡与非酒精性脂肪性肝病之间的关系
- Author:
Mingjian MA
1
;
Jian WU
2
Author Information
1. Department of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai 200082, China
2. Key Laboratory of Medical Molecular Virology, Ministry of Education and Public Health, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
- Publication Type:Review
- Keywords:
Fatty liver;
Gut microbiome;
Metabolism;
Intestinal permeability
- From:
Chinese Journal of Hepatology
2017;25(10):789-793
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of living standards in recent years, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has kept increasing, with 15%-30% in general population and 50%-90% in obese population. The "second-hit" theory has been widely recognized as the pathogenesis of NAFLD. In-depth studies have found that intestinal flora imbalance may promote the progression of NAFLD by increasing energy absorption in the body, damaging intestinal mucosal barrier, and producing large amounts of toxic metabolites, which provides a new direction for exploring the pathogenesis of NAFLD and effective therapies. This article reviews the role of intestinal flora imbalance in the development and progression of NAFLD.
