Research advances in chronicity of hepatitis E virus infection
10.3760/cma.j.issn.1007-3418.2017.10.016
- VernacularTitle: 戊型肝炎病毒感染慢性化的研究进展
- Author:
Yuanji MA
1
,
2
;
Hong TANG
Author Information
1. Center of Infectious Diseases, West China Hospital of Sichuan University
2. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
- Publication Type:Review
- Keywords:
Hepatitis E virus;
Treatment;
Prevention;
Chronic infection;
Pathogenesis
- From:
Chinese Journal of Hepatology
2017;25(10):785-788
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis E virus (HEV) infection usually causes acute hepatitis and has a self-limiting progression. The patients often recover within 6 months with good prognosis. Recent studies have found that HEV infection may become chronic in special situations, which manifests as persistent liver function abnormalities for at least 6 months after acute HEV infection and the presence of viral nucleic acid in serum, feces, and/or liver tissue. Chronicity of HEV infection mainly occurs in immunocompromised patients, and it is rare but very dangerous in clinical practice. An understanding of the pathogenesis, clinical manifestations, treatment methods, and preventive measures of chronicity of HEV infection helps clinical physicians develop an effective management regimen and improve patient prognosis. This article introduces related issues, in order to raise the awareness of this disease among clinical physicians.
