Risk factors and survival analysis for synchronous esophageal carcinoma in patients with hypopharyngeal carcinoma
10.3760/cma.j.issn.1673-0860.2017.10.007
- VernacularTitle: 下咽癌伴有同时性食管癌的危险因素及生存分析
- Author:
Qingqing ZHANG
1
;
Xiaoguang NI
1
;
Shun HE
1
;
Yueming ZHANG
1
;
Lizhou DOU
1
;
Shaoqing LAI
1
;
Guiqi WANG
1
Author Information
1. Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Journal Article
- Keywords:
Hypopharyngeal neoplasms;
Esophageal neoplasms;
Early detection of cancer;
Endoscopy;
Narrow-band imaging
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(10):749-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors and survival status of hypopharyngeal carcinoma with synchronous second primary carcinoma of the esophagus.
Methods:One hundred and sixty patients with newly diagnosed hypopharyngeal carcinoma from January 2009 to December 2012 were retrospectively reviewed. The clinical data, tumor-related information and follow-up results were collected and analyzed.
Results:Forty-three synchronous esophageal carcinomas (27%) were detected in 160 patients with hypopharyngeal carcinoma, and most patients (72%) were at an early stage. On univariate analysis, the median age of less than 55 years old (χ2=4.525, P=0.033), excessive alcohol consumption (χ2=6.942, P=0.008) and invasion site more than 3 anatomical regions (χ2=21.503, P=0.000) had a significant correlation with the occurrence of synchronous esophageal carcinomas. Multivariate analysis showed that excessive alcohol consumption (OR=4.787, P=0.029) and invasion site more than 3 anatomical regions (OR=14.391, P=0.000) were independent risk factors. The median survival time was 26 months in 43 patients with synchronous esophageal carcinomas, which was significantly lower than that (58 months) in patients without secondary primary esophageal carcinomas (χ2=11.981, P=0.001).
Conclusions:There is a high incidence of synchronous esophageal carcinoma in hypopharyngeal carcinoma patients, affecting the prognosis of hypopharyngeal carcinoma. Surveillance for esophageal carcinomas in patients with hypopharyngeal carcinoma, especially in excessive alcohol drinkers, is warranted.
