Diagnostic and prognostic roles of loss of CIC protein expression in oligodendroglial tumors
10.3760/cma.j.issn.0529-5807.2017.10.004
- VernacularTitle: CIC蛋白失表达在少突胶质细胞肿瘤诊断及预后判断中的意义
- Author:
Cuicui LIU
1
;
Liyan ZHANG
;
Leiming WANG
;
Dandan WANG
;
Yongjuan FU
;
Yanning CAI
;
Dehong LU
;
Yueshan PIAO
Author Information
1. Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
- Publication Type:Journal Article
- Keywords:
Oligodendroglioma;
Chromosome deletion;
Immunohistochemistry;
Prognosis;
CIC protein
- From:
Chinese Journal of Pathology
2017;46(10):679-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the usefulness of loss of CIC expression as the prescreening detection of 1p/19q co-deletion in the diagnosis of oligodendroglial tumors and its prognostic implication.
Methods:The retrospective study included 113 oligodendroglial tumors diagnosed in the Department of Pathology, Xuanwu Hospital, Capital Medical University. Expression of CIC protein was detected by immunohistochemistry, and the 1p/19q co-deletion by fluorescence in situ hybridization in all the tumors; and the correlation of the loss of protein and 1p/19q co-deletion with prognosis was assessed.
Results:The rate of negative CIC protein expression was 59.3% (67/113) in 113 oligodendroglial tumors. CIC protein expression was differentially lost in various gliomas, 85.7% (42/49) in pure oligodendrogliomas and 39.1% (25/64) in mixed oligodendroglial tumors (P<0.01). The loss of CIC protein expression showed a sensitivity of 76.1% (54/71), specificity 71.1% (27/38), false positive rate of 16.9% (11/65), and a false negative rate of 38.6% (17/44). In 63 cases integrated diagnosis as oligodendroglial tumors with mutant IDH and 1p/19q co-deletion, the loss of CIC protein expression was 81.0% (51/63); the sensitivity and specificity were increased to 81.0% (51/63) and 76.9% (20/26), and the false positive rate and false negative rate decreased to 10.5% (6/57) and 37.5% (12/32), respectively. By using Kaplan-Meier analysis, the CIC negative group showed a trend towards better outcome than the CIC positive group, but there was no statistical difference (overall survival: P=0.218; progression free survival: P=0.249).
Conclusions:Detection of the lost CIC protein expression can predict the chromosome 1p/19q co-deletion. In oligodendroglial tumors with IDH mutant and 1p/19q co-deletion, there is no relation between prognosis and CIC protein expression.
