The impact to operation safety of preoperative renal artery embolization for management of diameter≥10 cm renal cell carcinoma
10.3760/cma.j.issn.0529-5815.2017.10.004
- VernacularTitle: 术前肾动脉栓塞治疗对肿瘤最大径≥10 cm的肾细胞癌患者手术安全性的影响
- Author:
Zhuo JIA
1
;
Xuesong LI
;
Cuijian ZHANG
;
Kaiwei YANG
;
Ding PENG
;
Jinghua YANG
;
Changmin DING
;
Chenguang XI
;
Zhisong HE
;
Liqun ZHOU
Author Information
1. Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, renal cell;
Nephrectomy;
Embolization, therapeutic;
Postoperative complication
- From:
Chinese Journal of Surgery
2017;55(10):738-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the impact to operation safety of preoperative renal artery embolization for management of ≥10 cm renal cell carcinoma.
Methods:The clinical data of 239 cases with ≥10 cm renal cell carcinoma which all had underwent operation in Department of Urology, Peking University First Hospital from January 2002 to December 2014 were retrospectively analyzed. Fifty-three patients underwent preoperative renal artery embolization (therapeutic group) and 186 patients did not (control group). The effect of embolization on operative time, transfusion requirements, hospitalization, ICU stay and perioperative complications were analyzed by comparing the two groups using rank sum test and χ2 test or Fisher exact test.
Results:Comparing the therapeutic group and control group, there was significant difference in tumor location (on the left or right). The mean age, sex, mean primary tumor size, and TNM stage were similar in both groups. Comparing the therapeutic group and control group, there were more open surgeries in therapeutic group (96.2% vs. 82.3%, χ2=6.438, P=0.013). There were no significant differences in mean operative time (238 (525) minutes vs. 208 (583) minutes, Z=-2.182, P=0.062). The mean blood transfusion (700 (1 900) ml vs. 925 (8 800) ml, Z=-1.064, P=0.006) had significant difference. The therapeutic group had a longer mean hospitalization (21 (50) days vs. 15 (79) days, Z=-4.322, P=0.000) and higher rate of intensive care unit stay (54.7% vs. 34.4%, χ2=6.103, P=0.027). There was no significant difference in perioperative complications between two groups (0 vs.3.2%, P=0.408).
Conclusion:Preoperative renal artery embolization in ≥10 cm renal cell carcinoma patients undergoing operation provides benefit in increasing operation safety and reducing perioperative death.
