Biomaterials for bone defect repair and bone regeneration
10.3760/cma.j.issn.1002-0098.2017.10.004
- VernacularTitle: 骨缺损修复生物材料与骨再生
- Author:
Xinquan JIANG
1
Author Information
1. Department of Prosthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology & National Clinical Research Center of Stomatology, Shanghai 200011, China
- Publication Type:Journal Article
- Keywords:
Stem cells;
Biocompatible materials;
Tissue engineering;
Regenerative medicine
- From:
Chinese Journal of Stomatology
2017;52(10):600-604
- CountryChina
- Language:Chinese
-
Abstract:
The treatment of large jaw bone defects remains an urgent clinical problem to be solved. With the development of biomaterials, stem cells and bone tissue engineering, new ideas and hopes for the regeneration of jaw have been offered. In addition to meeting the basic requirements of bone repair materials, scaffolds for the regeneration of large jaw bones require the ability of stem cells to participate in bone regeneration. Methods like optimization of scaffolds composition, design of porous structure and combination of gel and microsphere technology can enhance stem cell delivery in vivo, and the osteogenic differentiation of stem cells can be stimulated through controlled release of drugs, preparation of surface micron/nano topography and modifications of ionic components. Moreover, application of three-dimensional printing and channel structure in large-scale scaffolds fabrication present promising strategies for customized, accurate bone reconstruction and vascularization. It is only through synergistic optimization in all aspects that it is possible to obtain scaffold materials suitable for regeneration of large jaw bones. This article focuses on biological materials regulation, stem cell delivery, survival and differentiation, and their role in bone regeneration.
