The epidemiological characteristics and drug resistance of mycoplasma pneumoniae in patients with community-acquired pneumonia during 2011-2015 in 5 sentinel hospitals in Beijing
10.3760/cma.j.issn.0253-9624.2017.09.011
- VernacularTitle: 2011—2015年北京5家哨点医院社区获得性肺炎病例中肺炎支原体流行特征及耐药情况
- Author:
Weixian SHI
1
;
Shuangsheng WU
;
Cheng GONG
;
Aihua LI
;
Fang HUANG
Author Information
1. Beijing Centers For Disease Control & Prevention, Beijing Research Center for Preventive Medicine, Beijing 100013, China
- Publication Type:Journal Article
- Keywords:
Patients with community-acquired pneumonia;
Mycoplasma pneumoniae;
Epidemic characteristics
- From:
Chinese Journal of Preventive Medicine
2017;51(9):832-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and drug resistance of mycoplasma pneumoniae in patients with community-acquired pneumonia during 2011-2015 in Beijing.
Methods:Totally 2 272 mycoplasma pneumoniae samples were collected from patients with community-acquired pneumonia in 5 sentinel hospitals during 2011-2015. Mycoplasma pneumoniae were detected by real-time PCR. 142 copies of positive samples with Ct value under 30 were cultured to get the strains so that the genotypes based on the P1 gene sequence and the drug resistance based on the in vitro drug resistance test could be conducted. χ2 test was used to compare the detection rates of mycoplasma pneumoniae among different age groups and different onset-phase.
Results:The positive rate of mycoplasma pneumoniae was 13.6%(308 cases). The positive rate in groups aging (5-14), (15-24) and ≥60 years old were separately 24.4% (67/275), 24.4% (38/156) and 3.9% (28/727) (χ2=1.22, P<0.001). The annual detection rate of mycoplasma pneumoniae in 2011-2015 were 14.6% (73/501), 10.2% (36/353), 26.4% (101/383), 10.3% (41/398), 9.0% (57/637),respectively (χ2=72.65, P<0.001). Seasonally, the peak of positive rate was between October and December (17.5%, 122/699) and the lowest positive rate was between April and June (8.6%, 43/502). 36 strains were isolated from 142 swabs and 23 (63.9%) were P1-Ⅰ and 13 (36.1%) were P1-Ⅱ by genotyping. All isolates were susceptible to the fluoroquinolones (levofloxacin, ciprofloxacin, and gatifloxacin) and tetracycline. All P1-Ⅱ strains were susceptible to macrolides while most of the P1-Ⅰ strains (22 strains) were macrolide-resistant.
Conclusion:People aging (5-14) and (15-24) years old were more susceptible to mycoplasma pneumoniae in patients with community-acquired pneumonia in Beijing between 2011 and 2015. The highest positive rate of mycoplasma pneumoniae was in 2013 and the case distributed in all seasons. The major popular genotype was P1-Ⅰ, whose strains were mostly macrolide-resistant.