Cytogenetic abnormalities and prognosis of 532 patients with multiple myeloma
10.3760/cma.j.issn.0253-2727.2017.09.002
- VernacularTitle: 532例多发性骨髓瘤患者细胞遗传学异常及对预后的影响
- Author:
Hao WU
1
;
Hui ZHANG
;
Haiyan HE
;
Hua JIANG
;
Yunyang ZHAO
;
Ran AN
;
Jie HE
;
Rong LI
;
Jing LU
;
Jian HOU
Author Information
1. Department of Hematology, Chang Zheng Hospital, The Second Military Medical University, Shanghai 200003, China
- Publication Type:Journal Article
- Keywords:
Multiple, myeloma;
Cytogenetics;
Fluorescence in situ hybridization;
Prognosis
- From:
Chinese Journal of Hematology
2017;38(9):739-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of 6 common cytogenetic abnormalities on the prognosis of multiple myeloma (MM).
Methods:Myeloma cells from a cohort of 532 newly-diagnosed MM patients enrolled were enriched by CD138 immunomagnetic beads, then detected 13q-, 17p-, 1q+, t (4;14), t (11;14) and t (14;16) and other common genetic abnormalities in MM by using interphase fluorescence in situ hybridization (FISH) technique to compare the influence of different genetic abnormalities on their prognoses.
Results:The rate of cytogenetic abnormalities was 78.20% (416/532) in 532 patients, of which 13q-accounted for 42.29% (225/532), 17p-16.35% (87/532), 1q+ 53.38% (284/532), t (4;14) 25.94% (138/532), t (11;14) 21.62% (115/532), t (14;16) 2.07% (11/532). Six kinds of cytogenetic abnormalities were analyzed, 13q- and 17p-, 1q+, t (4; 14), t (14;16) were all correlated (P <0.05). The univariate analysis indicated that 13q-, 1q+, t (4;14) and t (14;16) had a significant effect on progression-free survival (PFS), 13q-, 17p-, t (4;14) and t (14;16) had a marked influence on overall survival (OS). The multivariate analysis showed that 1q+, t (4;14) and t (14;16) were independent adverse factors of PFS, 17p-, t (4;14) and t (14;16) were independent unfavorable factors of OS. According to the independent prognosis factors number-based groups, the median PFS with 0, 1, 2, 3 independent prognosis factors of patients were 30.9, 28.4, 18.7 and 17.6 months (P =0.035) respectively, and the median OS were 54.4, 46.1, 38.0 and 21.2 months (P =0.004) respectively.
Conclusion:1q+, 17p-, t (4;14) and t (14;16) were independent prognostic factors affecting the survival of MM patients. 13q-is often accompanied by 17p-, 1q + and (or) t (4;14) , simply 13q- was not an independent prognostic factor; the more number of independent prognostic factors, the worse the prognosis of patients.
