Impact factor of postoperative prognosis of esophageal cancer patients with stage pT2N0~1M0
10.3760/cma.j.issn.0253-3766.2017.09.009
- VernacularTitle: 影响pT2N0～1M0期胸段食管癌患者术后疗效的因素分析
- Author:
Yuhua GAO
1
;
Yuxiang WANG
2
;
Jing LI
2
;
Ming HE
3
;
Zhan QI
3
;
Rong QIU
2
;
Xueying QIAO
2
Author Information
1. Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China (Currently address: Department of Medical Oncology, the Second Central Hospital of Baoding, Zhuozhou 072750, China)
2. Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
3. Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Clinical Trail
- Keywords:
Esophageal neoplasms;
Esophagectomy;
Prognosis
- From:
Chinese Journal of Oncology
2017;39(9):683-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the postoperative prognosis and the related factors of patients with stage pT2N0-1M0 of thoracic esophageal carcinoma(EC).
Methods:From 2008 to 2011, clinical data of 275 cases with stage pT2N0-1M0 of thoracic EC treated by esophagectomy were enrolled. These cases includ 180 male and 95 female. Among them, 32 cases were upper thoracic EC, 186 cases were middle thoracic EC and 57 cases were lower thoracic EC. Alternatively, 205 cases were stage pN0, 70 cases were stage pN1. 155 cases received esophagectomy alone and 120 cases received esophagectomy and postoperative adjuvant therapy.
Results:The end of follow-up time was on September 30th, 2014. The 1-, 3-, 5-year overall survival (OS) rates were 91.6%, 70.2% and 63.7%, respectively. The 1- 3-, 5-year progression-free survival (PFS) rates were 83.9%, 64.0% and 60.0%, respectively. The result of univariate analysis showed that the depth of tumor invasion, pathological type, pN stage and number of metastatic lymph nodes were significantly associated with OS (all of P<0.05). Moreover, the gender, the depth of tumor invasion, pathological type, pN stage and number of metastatic lymph nodes were significantly associated with PFS (all of P<0.05). Cox multivariate analysis showed that the location of primary tumor and pN stage were the independent factors of OS (both P<0.05). The gender, pN stage and postoperative adjuvant therapy were the independent factors of PFS (all of P<0.05).
Conclusion:Among the patients with pT2N0~1M0 stage of thoracic EC, patients with upper thoracic EC or pN1 stage have poorer postoperative prognosis compared with others, and postoperative adjuvant treatment is recommended for these patients.
