Advances in clinical differentiation between immunological and drug-induced liver injury
10.3760/cma.j.issn.1007-3418.2017.09.014
- VernacularTitle: 免疫性和药物性肝损伤临床鉴别的新进展
- Author:
Yi WANG
1
;
Yanni LI
;
Jie ZHANG
;
Bangmao WANG
;
Lu ZHOU
Author Information
1. Department of Gastroenterology and Hepotology, Tianjin Medical University General Hospital, Tianjin 300052, China
- Publication Type:Review
- Keywords:
Hepatitis, autoimmune;
Hepatitis, toxic;
Diagnosis, differential;
Pathology;
Serology
- From:
Chinese Journal of Hepatology
2017;25(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
The differentiation between autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) is a difficult task in clinical practice. Some AIH patients had a medication history before disease onset, and some DILI patients may have positive serum antibody. In addition, these two groups of patients have similar clinical symptoms, serological examination results, and liver histopathology, which lead to the difficulties in differentiation. However, correct differential diagnosis is of great significance in making clinical treatment decisions and preventing liver cirrhosis. Therefore, it is necessary to investigate the association between immunological and drug-induced liver injury from the perspectives of pathogenesis, similarities and differences in clinical features, serological examination results, and histological changes, prospects of new biomarkers in differentiation, and the significance of hormone therapy and clinical follow-up in differential diagnosis and treatment, in order to provide a reference for clinical decision-making and research in future.
