Clinical research on immune checkpoint and head and neck squamous cell carcinoma
10.3760/cma.j.issn.1673-0860.2017.09.017
- VernacularTitle: 免疫检查点与常见头颈部鳞状细胞癌的临床研究现状
- Author:
Dan YU
1
;
Xinmeng QI
1
;
Xue ZHAO
1
;
Yan LIU
1
;
Kai XUE
1
;
Chunshun JIN
1
;
Lianji WEN
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery, the Second Hospital of Jilin University, Changchun 130041, China
- Publication Type:Review
- Keywords:
Head and neck neoplasms;
Carcinoma, squamous cell;
CTLA-4;
PD1/PDL1 molecular;
Immune checkpoint;
Immunotherapy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
T cell immune checkpoint pathways contribute to tumor immune escape. Many studies have shown that immune checkpoint is demonstrably correlated with tumor grade or prognosis in several types of malignancies and immune checkpoint has become a new biological index for tumor detection and prognosis. Immune checkpoint inhibitors have shown promising tumor outcomes in clinical trials for some advanced solid tumors and it will become a new target for cancer immunotherapy. In this review we will explore the correlation between expressions of immune checkpoint-associated genes and proteins in immune microenviroment and prognosis of head and neck squamous cell carcinoma, and specifically will discuss how this pathway can be manipulated with immune therapeutic drugs.
