Clinicopathologic and prognosis features of Claudin-low breast cancers
10.3760/cma.j.issn.0529-5807.2017.09.009
- VernacularTitle: Claudin-low型乳腺癌的临床病理及预后特征
- Author:
Jing XU
1
;
Ketao LAN
;
Tianhui SU
;
Zhenfeng LI
;
Yue WAN
;
Qinqin GU
;
Pengcheng ZOU
;
Xiao ZOU
Author Information
1. Department of Pathology, Qingdao Central Hospital, Qingdao 266042, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Claudins;
Molecular typing;
Prognosis
- From:
Chinese Journal of Pathology
2017;46(9):634-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathologic and prognostic features of Claudin-low breast cancers (CLBC).
Methods:Tissue microarray sections were scored semiquantitatively for the immunohistochemical expression of claudin-1, -3, -4, -7 and -8 in 233 cases of invasive breast cancers collected from Qingdao Central Hospital from January 2010 to December 2011.
Results:The expression rate of Claudin-3 (72/212, 33.9%) and -4 (56/212, 45.2%) was most similar, and Claudin-4 showed the highest expression. Twenty one cases (21/212, 9.0%) were diagnosed as CLBC, with triple-negative breast cancer (TNBC) accounted for the highest proportion (11/21, 52.4%). Among the CLBC cases, the invasive carcinoma no special type (66.7%, 14/21) and metaplastic carcinoma (14.3%, 3/21) were mostly seen, while metaplastic squamous carcinoma did not show Claudin-low pattern. Compared to the non CLBC in this cohort, CLBC had higher proportion of histologic grade 3 and tumors larger than 2 cm, and the proportions were slightly lower than TNBC. Patients with CLBC had lower 5 year disease-free(P>0.05) and overall survival rates(P=0.018).
Conclusion:CLBC shows distinct clinicopathologic and prognostic features comparing to other subtypes, and is associated with poor prognosis.
