Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 27 cases
10.3760/cma.j.issn.0529-5807.2017.09.004
- VernacularTitle: 原发纵隔大B细胞淋巴瘤27例临床病理特征
- Author:
Qianyun SHI
1
;
Xiao FENG
;
Hui CHEN
;
Henghui MA
;
Zhenfeng LU
;
Qunli SHI
;
Xiaojun ZHOU
;
Qin SHEN
Author Information
1. Department of Pathology, Nanjing General Hospital of PLA, Nanjing Medical University, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
Lymphoma, B-cell;
Mediastinal neoplasms;
Diagnosis, differential
- From:
Chinese Journal of Pathology
2017;46(9):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic characteristics and diagnostic criteria of primary mediastinal B-cell lymphoma (PMBL), and to distinguish PMBL from classic Hodgkin lymphoma(CHL) and systemic diffuse large B-cell lymphoma(DLBCL).
Methods:The clinical features, histologic findings, results of immunohistochemical study and prgnosis in 27 PMBL cases were analyzed, with review of literature.
Results:The age of patients ranged from 19 to 82 years (median age 34 years). All cases were located in the mediastinum and frequently accompanied by superior vein cava syndrome. Histologically, the tumor cells were pleomorphic and diffusely distributed. Clear cytoplasm and spindle tumor cells were seen in some cases. Varying amount of sclerosing stroma with collagen deposition was seen.Immunohistochemical study showed that the tumor cells were positive for CD20(100%, 27/27), CD30 (64.0%, 16/25), CD23 (77.3%, 17/22) and p63 (16/19). Clonal B cell gene rearrangement was seen.
Conclusions:PMBL is a subtype of diffuse large B-cell lymphoma with various histomorphology. Immunohistochemistry can help to confirm the diagnosis, and the prognosis is better than diffuse large B cell lymphoma, not otherwise specified.
