Predictive value of serial platelet function testing on outcome in patients undergoing complex percutaneous coronary intervention
10.3760/cma.j.issn.0253-3758.2017.09.008
- VernacularTitle: 血小板功能系列检测对接受复杂经皮冠状动脉介入治疗患者临床结局的预测价值
- Author:
Mengmeng LI
1
;
Quan LI
;
Xuejun REN
;
Xianpeng YU
;
Jiqiang HE
;
Yuechmm GAO
;
Changyan WU
;
Yawei LUO
;
Yuchen ZHANG
;
Fang CHEN
;
Xiaoling ZHANG
Author Information
1. Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Capital Medical University, Beijing 100029, China
- Publication Type:Clinical Trail
- Keywords:
Coronary artery disease;
Angioplasty;
Platelet function tests
- From:
Chinese Journal of Cardiology
2017;45(9):770-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the predictive value of serial platelet function testing (PFT) on outcome in patients undergoing complex percutaneous coronary intervention (PCI).
Methods:Six hundred and two consecutive patients undergoing complex PCI in Anzhen hospital were enrolled during October 2011 to June 2012.Adenosine diphosphate(ADP)-induced platelet aggregation was measured by light transmission aggregometry on the first, sixth and twelfth month after PCI and the mean value was calculated.The cut-off value of high on-treatment platelet reactivity (HTPR) was defined as 40%.The primary endpoint was major adverse cardiovascular and cerebral event (MACCE). Clinical outcomes were analyzed by the Kaplan-Meier method and differences were compared using the log-rank test.Multivariate analyses by Cox proportion hazards regression were applied to identify variables independently associated with the adverse outcomes.
Results:Five hundred and eighty-five patients (HTPR, n=285; non-HTPR, n=280) finished the follow-up ((28.47±7.45) months). A total of 33 cases of MACCE were observed during the follow-up, among which 29 cases(8.42%) were in HTPR group and 9 cases (3.21%) in the non-HTPR group.Kaplan-Meier analysis suggested that HTPR was associated with an increased incidence of MACCE (log-rank test, P=0.01). The Cox multivariate analysis indicated that HTPR was an independent risk factor of MACCE (HR=2.69, 95%CI 1.23-5.85, P=0.01) in patients undergoing complex PCI.Incidence of MACCE was similar between HTRP patients receiving standard dual antiplatelet therapy (DAPT) or prolonged DAPT (>12 months).
Conclusion:Serial PFT could predict the long-term prognosis of patients underwent complex PCI.
