Study of the association between interleukin-1 polymorphisms and genetic susceptibility of coal workers’ pneumoconiosis and silicosis
10.3760/cma.j.issn.1001-9391.2017.09.006
- VernacularTitle: 白细胞介素-1基因遗传变异与煤工尘肺及矽肺易感性的meta分析
- Author:
Wei WANG
1
;
Wuhong ZHANG
;
Yusha TAO
;
Xun ZHUANG
;
Minjie CHU
Author Information
1. Department of Occupational Health, Center for Disease Control and Prevention of Wuxi, Wuxi 214000, China
- Publication Type:Journal Article
- Keywords:
Interleukin-1;
Pneumoconiosis;
Silicosis;
Meta-analysis;
Polymorphism, signle nucleotide
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2017;35(9):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between IL-1 gene polymorphisms and coal workers’ pneumoconiosis and silicosis susceptibility.
Methods:We searched published full-text from PubMed, Web of Science, CNKI, VIP and Wanfang to collect case-control study on IL-1 gene polymorphisms with coal workers’ pneumoconiosis and silicosis susceptibility. Eight articles, including 10 case-control studies were included in our study. All analyses were performed using the Stata version 12.0 software.
Results:The IL-1RA (+2018) TC or CC variant genotypes were associated with coal workers’ pneumoconiosis and silicosis risk (OR=1.65, 95%CI: 1.11-2.46) . In further stratified analyses, the IL-1RA (+2018) TC or CC variant genotypes were associated with an increased silicosis risk (OR=2.07, 95%CI: 1.45-2.95) , which were also associated with increased coal workers’ pneumoconiosis and silicosis risk in Caucasians (OR=1.74, 95%CI: 1.22-2.47) . No significant association between IL-1β (+3953) , IL-1β (-511) , IL-1α (+4845) and coal workers' pneumoconiosis and silicosis risk was found either in the overall study or in the stratified analysis.
Conclusion:These findings suggested that IL-1RA (+2018) may modify coal workers’ pneumoconiosis and silicosis susceptibility. Further replication studies with large sample sizes are warranted to re-evaluate the relationship between IL-1RA (+2018) and coal workers’ pneumoconiosis and silicosis risk.
