Clinical analysis of 7 patients with Epstein-Barr virus encephalitis after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.0253-2727.2017.08.007
- VernacularTitle: 异基因造血干细胞移植后EB病毒脑炎七例临床分析
- Author:
Peng KE
1
;
Xiao MA
;
Xiebing BAO
;
Yuejun LIU
;
Xiaojin WU
;
Shengli XUE
;
Xiaohui HU
;
Xuefeng HE
;
Depei WU
Author Information
1. First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis under Ministry of Health, Collaborative Innovation Center of Hematology, Institute of Blood and Marrow Transplantation, Soochow University, Suzhou 215006, China
- Publication Type:Journal Article
- Keywords:
EBV encephalitis;
Hematopoietic stem cell transplantation;
Rituximab
- From:
Chinese Journal of Hematology
2017;38(8):685-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical features, treatment and prognosis of patients with Epstein Barr virus (EBV) encephalitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT) .
Methods:The clinical data of 7 patients with EBV encephalitis who had undergone allo-HSCT in the First Affiliated Hospital of Soochow University from January 2012 to December 2015 were reviewed.
Results:The incidence of EBV encephalitis was 0.70% (7/998) , and the median time was 63 (10-136) d after allo-HSCT. Seven patients had fever and mental disorder, of whom 4 cases of brain MRI were positive. Two patients received HLA-matched unrelated transplantation, while other 5 ones received haploidentical allo-HSCT. In conditioning regimen process, 7 patients were combined with anti-thymocyte globulin (ATG) to prevent graft versus host disease (GVHD) , of whom 6 patients had grade Ⅱ-Ⅳ acute GVHD. All patients of EBV-DNA were negative in CSF after taking anti-virus agent Rituximab. Until the last follow-up, a total of 3 patients died, 2 died of leukemia recurrence, 1 EBV encephalitis progression.
Conclusion:Once suspected EBV encephalitis after allo-HSCT, brain MRI and EBV-DNA in CSF should be detected, which could improve early diagnosis of EBV encephalitis. The usage of Rituximab was effective and well tolerated.
