Epigenetics and liver fibrogenesis
10.3760/cma.j.issn.1007-3418.2017.08.004
- VernacularTitle: 表观遗传与肝纤维化发生
- Author:
Yuanqing ZHANG
1
;
Jinsheng GUO
Author Information
1. Division of Digestive Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Epigenetics;
Gene
- From:
Chinese Journal of Hepatology
2017;25(8):571-574
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic modification refers to a variety of regulating processes that may induce the changes in gene expression without altering DNA sequence. Epigenetic mechanisms including DNA methylation, histone modification, and regulatory non-coding RNAs are involved in hepatic stellate cell activation and liver fibrogenesis. A deep understanding of epigenetic mechanisms in liver fibrosis helps to identify new markers and therapies for liver fibrosis.
