Distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015: results from a multicenter, retrospective study
10.3760/cma.j.issn.0253-2727.2017.07.010
- VernacularTitle: 2014至2015年江苏省血液科病房病原菌分布及耐药状况的多中心回顾性研究
- Author:
Yike WAN
1
;
Wei SANG
;
Bing CHEN
;
Yonggong YANG
;
Luqin ZHANG
;
Aining SUN
;
Yuejun LIU
;
Yang XU
;
Yipeng CAI
;
Chunbin WANG
;
Yunfeng SHEN
;
Yangwen JIANG
;
Xiaoyan ZHANG
;
Wei XU
;
Ming HONG
;
Tao CHEN
;
Ruirong XU
;
Feng LI
;
Yanli XU
;
Yan XUE
;
Yilong LU
;
Zhengmei HE
;
Weimin DONG
;
Ze CHEN
;
Meihua JI
;
Yueyan YANG
;
Lijia ZHAI
;
Yu ZHAO
;
Guangqi WU
;
Jiahua DING
;
Jian CHENG
;
Weibo CAI
;
Yumei SUN
;
Jian OUYANG
1
Author Information
1. The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
Hematologic disease;
Bacterial infection and mycoses;
Microbial sensitivity test
- From:
Chinese Journal of Hematology
2017;38(7):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment.
Methods:Pathogens were from hematology department of 26 tertiary hospitals in Jiangsu Province from 2014 to 2015. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or agar dilution method. Collection of drug susceptibility results and corresponding patient data were analyzed.
Results:The separated pathogens amounted to 4 306. Gram-negative bacteria accounted for 64.26%, while the proportions of gram-positive bacteria and funguses were 26.99% and 8.75% respectively. Common gram-negative bacteria were Escherichia coli (20.48%) , Klebsiella pneumonia (15.40%) , Pseudomonas aeruginosa (8.50%) , Acinetobacter baumannii (5.04%) and Stenotropho-monas maltophilia (3.41%) respectively. CRE amounted to 123 (6.68%) . Common gram-positive bacteria were Staphylococcus aureus (4.92%) , Staphylococcus hominis (4.88%) and Staphylococcus epidermidis (4.71%) respectively. Candida albicans were the main fungus which accounted for 5.43%. The rates of Escherichia coli and Klebsiella pneumonia resistant to carbapenems were 3.5%-6.1% and 5.0%-6.3% respectively. The rates of Pseudomonas aeruginosa resistant to tobramycin and amikacin were 3.2% and 3.3% respectively. The resistant rates of Acinetobacter baumannii towards tobramycin and cefoperazone/sulbactam were both 19.2%. The rates of Stenotrophomonas maltophilia resistant to minocycline and sulfamethoxazole were 3.5% and 9.3% respectively. The rates of Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis resistant wards vancomycin were 0, 6.4% and 1.4% respectively; also, the rates of them resistant to linezolid were 1.2%, 0 and 1.6% respectively; in addition, the rates of them resistant to teicoplanin were 2.8%, 14.3% and 8.0% respectively. Furthermore, MRSA accounted for 39.15% (83/212) .
Conclusions:Pathogens were mainly gram-negative bacteria. CRE accounted for 6.68%. The rates of Escherichia coli and Klebsiella pneumonia resistant to carbapenems were lower compared with other antibacterial agents. The rates of gram-positive bacteria resistant to vancomycin, linezolid and teicoplanin were still low. MRSA accounted for 39.15%.
