Evaluation of efficacy of 1 year after completing the 2-year specific sublingual immunotherapy treatment course in allergic rhinitis
10.3760/cma.j.issn.1673-0860.2017.07.004
- VernacularTitle: 舌下免疫治疗变应性鼻炎满2年终止1年的疗效分析
- Author:
Liang HAN
1
;
Quanjie YOU
1
;
Zhi LI
1
;
Huanhuan YANG
1
;
Hong FANG
1
;
Yue ZHANG
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
- Publication Type:Journal Article
- Keywords:
Rhinitis, allergic;
Administration, sublingual;
Immunity;
Treatment outcome;
Dermatophagoides farinae
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2017;52(7):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of treatment at 1 year after completing the 2-year specific sublingual immunotherapy in patients with allergic rhinitis (AR).
Methods:A retrospective analysis of 124 patients with AR who were allergic to dust mite and treated in the First Affiliated Hospital of Wenzhou Medical University since 2012 was performed. All patients achieved sublingual immunotherapy (SLIT) for 2 years and had a regular follow-up over 1 year. Efficacy evaluation index such as VAS score, total nasal symptom score and total medication score were compared between the time of SLIT for 2 years, and 1 year after termination of SLIT. Paired t test was used for the comparison of scores.
Results:Compared with those before treatment, the VAS score, total nasal symptom score and total medication score at the time of SLIT for 2 years were significantly decreased in all patients with AR [(9.40±5.96) vs (24.78±6.36), (4.53±2.06) vs (9.51±2.02), (0.42±0.87) vs (3.02±0.41), t value was 17.627, 24.600, 5.331, respectively, all P<0.01]. Compared with 2 years SLIT treatment, VAS score and total nasal symptom score were significantly increased than 1 year after termination of immunotherapy [(12.52±6.92) vs (9.40±5.96), (5.30±2.36) vs (4.53±2.06), t=5.199, 3.744, respectively, all P<0.01], but the total medication score showed no significant difference [(0.34±0.84) vs (0.42±0.87), t=-1.043, P>0.05].
Conclusions:The symptoms after 2 years SLIT in patients with AR have been well controlled. One year after the termination of SLIT, there is a certain rebound in symptoms, 2 years SLIT may not be the ideal treatment cycle for AR.
